Hoodia gordonii is a succulent found in the Kalahari Desert of South Africa. The
San Tribesmen of the Kalahari have been using hoodia as a food source for
thousands of years.Click here to buy Hoodia Extract supplement
Hoodia Research, weight loss and appetite suppression
Hoodia gordonii is traditionally used in South Africa
for its appetite suppressant properties. Based
on the media attention hoodia has garnered, you would think there has been a lot
of research on hoodia. But there has been very little hoodia research published,
particularly human hoodia research.
Hoodia is available as a supplement in various extract forms, and
it is also available in combination with other herbs and supplements for those
interested in better body weight management. One such effective appetite
suppressant is Diet Rx with hoodia gordonii, formulated by world famous medical
doctor, Dr. Ray Sahelian, M.D.
Hoodia Extract 400
mg,
Hoodia Gordonii extract 20:1
Note:
This hoodia product is a 20:1 extract which means it
is 20 times as concentrated as regular
hoodia plant. Four hundred mgs of Hoodia extract equals about 8,000 mg or 8 grams of the actual plant.
Hoodia gordonii is a succulent found in the Kalahari Desert of South Africa. The
San Tribesmen of the Kalahari have been using hoodia as a food source for
thousands of years.
Click here to buy Hoodia Extract supplement
Supplement Facts
Hoodia gordonii Stem Extract (20:1) - 400 mg *
Suggested Use: 1 or 2 hoodia capsules in the morning before breakfast on an empty
stomach.
* Hoodia daily value not established.
Diet Rx with Hoodia Extract
All Natural
Appetite Suppressant
Decreases appetite so you eat less
Helps you maintain healthy blood sugar levels
Helps you maintain healthy cholesterol and lipid levels
Provides a variety of antioxidant from two dozen herbs and nutrients
Hoodia research -
glycosides
New calogenin glycosides from Hoodia gordonii.
Steroids. 2007 Nov;72(13):881-91. Epub 2007 Jul 27. Pawar RS, Shukla YJ, Khan IA.
National Center for Natural Products Research, Research Institute of
Pharmaceutical Sciences, University of Mississippi, University, MS 38677, USA.
Ten new pregnane glycosides (1, 3-11) were isolated from organic extracts of
aerial parts of Hoodia gordonii. The aglycone was identified as calogenin.
Steroidal glycosides from Hoodia gordonii.
Steroids. 2007 Jun;72(6-7):559-68. Dall'Acqua S, Innocenti G. Department of
Pharmaceutical Sciences, University of Padova, Via F. Marzolo 5, 35131 Padova,
Italy.
Ten new C21-steroidal derivatives, namely gordonosides A-L (1-10) were isolated
from a chloroform extract of the aerial parts of Hoodia gordonii, a plant widely
used in the nutraceutical market as an ingredient of weight loss supplements.
New oxypregnane glycosides from appetite suppressant
herbal supplement Hoodia gordonii.
Steroids. 2007 Jun;72(6-7):524-34. Pawar RS, Shukla YJ, Khan SI, Avula B,
Khan IA. National Center for Natural Products Research, Research Institute of
Pharmaceutical Sciences, University of Mississippi, University, MS 38677, USA.
Hoodigosides A-K (1-11), eleven new oxypregnane glycosides and a previously
reported oxypregnane glycoside P57AS3 were isolated from the aerial parts of
Hoodia gordonii. Cytotoxicity and antioxidant activities of these compounds were
tested in cell based assays where they were found to be inactive.
Hoodia P57 research
Determination of the appetite suppressant P57 in Hoodia gordonii plant extracts
and dietary supplements by liquid chromatography/electrospray ionization mass
spectrometry (LC-MSD-TOF) and LC-UV methods.
J AOAC Int. 2006 May-Jun;89(3):606-11. Avula B, Wang YH, Pawar RS, Shukla YJ,
Schaneberg B, Khan IA.
National Center for Natural Products Research, Research Institute of
Pharmaceutical Sciences, The University of Mississippi, MS 38677, USA.
P57AS3 ( P57 ), an oxypregnane steroidal glycoside, is the only reported active
constituent from the hoodia plant as an appetite suppressant. New methods of
liquid chromatography/mass spectrometry (LC/MS) and LC-UV for analysis of P57
from Hoodia gordonii have been developed. The quantitative determination of P57
was achieved with a Phenomenex Gemini (Torrance, CA) reversed-phase column using
gradient mobile phase of water and acetonitrile. Good results were obtained in
terms of repeatability and recovery. The developed methods were applied to the
determination of P57 for Hoodia gordonii plant samples, one related genus (Opuntia
ficus-indica), and dietary supplements that claim to contain Hoodia gordonii.
Increased ATP content/production in the hypothalamus
may be a signal for energy-sensing of satiety: studies of the anorectic
mechanism of a plant steroidal glycoside.
Brain Res. 2004 Sep 10;1020(1-2):1-11. MacLean DB, Luo LG. Division of
Endocrinology, Hallett Center for Diabetes and Endocrinology, Brown Medical
School, Coro Building Providence, RI 02903, USA.
A steroidal glycoside with anorectic activity in animals, termed P57AS3 ( P57 ),
was isolated from Hoodia gordonii and found to have homologies to the steroidal
core of cardiac glycosides. Intracerebroventricular (i.c.v.) injections of the
purified P57 AS3 demonstrated that the compound has a likely central (CNS)
mechanism of action. There is no evidence of P57 AS3 binding to or altering
activity of known receptors or proteins, including Na/K-ATPase, the putative
target of cardiac glycosides. The studies demonstrated that the compound
increases the content of ATP by 50-150% in hypothalamic neurons. In addition,
third ventricle (i.c.v.) administration of P57, which reduces subsequent 24-h
food intake by 40-60%, also increases ATP content in hypothalamic slice punches
removed at 24 h following the i.c.v. injections. In related studies, in pair fed
rats fed a low calorie diet for 4 days, the content of ATP in the hypothalami of
control i.c.v. injected animals fell by 30-50%, which was blocked by i.c.v.
injections of P57 AS3. With growing evidence of metabolic or nutrient-sensing by
the hypothalamus, ATP may be a common currency of energy sensing, which in turn
may trigger the appropriate neural, endocrine and appetitive responses as
similar to other fundamental hypothalamic homeostatic centers for temperature
and osmolarity.
Hoodia research - appetite
suppressant
An appetite suppressant from Hoodia species.
Phytochemistry. 2007 Jun 29; van Heerden FR, Marthinus Horak R, Maharaj VJ,
Vleggaar R, Senabe JV, Gunning PJ.
School of Chemistry, University of KwaZulu-Natal, Private Bag X01, Scottsville
3209, South Africa.
Studies conducted at the Council for Scientific and Industrial Research (CSIR,
South Africa) identified extracts from Hoodia species, in particular Hoodia
pilifera and Hoodia gordonii, as possessing appetite suppressing properties. Two
pregnane glycosides were isolated by fractionation of the dried stems of H.
gordonii. Compounds 1 and 2 were also isolated from H. pilifera. Compound 1 was
tested for its appetite suppressant properties in rats by oral gavage at
6.25-50mg/kg and the results showed that all doses resulted in a decrease of
food consumption over an eight day period and a body mass decrease when compared
to the control sample. In a comparative study against a fenfluramine control
sample, compound 1 resulted in a reduction in food intake over the study period,
with a concomitant overall decrease in body weight while fenfluramine resulted
in a small decrease in food intake, but an increase in body weight (though less
than control group) over the same period of time.
Hoodia gordonii research
questions
Q. I read somewhere that "Hoodia works by increasing the ATP levels in the
hypothalamus of the brain initiating satiety within the body. When one feels
satisfied, endorphins are released that makes the body feel happy, energized,
and not hungry. " Is this true?
A. It appears that one research paper has referred to this
mechanism as an explanation of hoodia and its effect on satiety.